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Utilization of Myosin and Actin Bundles for the Transport of Molecular Cargo
Author(s) -
Takatsuki Hideyo,
Rice Kevin M.,
Asano Shinichi,
Day B. Scott,
Hino Mizuki,
Oiwa Kazuhiro,
Ishikawa Ryoki,
Hiratsuka Yuichi,
Uyeda Taro Q. P.,
Kohama Kazuhiro,
Blough Eric R.
Publication year - 2010
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200901369
Subject(s) - myosin , molecular motor , actin , motor protein , nanotechnology , biophysics , actin remodeling , materials science , microbiology and biotechnology , actin cytoskeleton , chemistry , cytoskeleton , microtubule , biology , biochemistry , cell
The utilization of motor proteins for the movement and assembly of synthetic components is currently a goal of nanoengineering research. Application of the myosin actin motor system for nanotechnological uses has been hampered due to the low flexural rigidity of individual F‐actin filaments. Here it is demonstrated how actin bundling can be used to affect the translational behavior of myosin‐propelled filaments, transport molecules across a motor‐patterned surface, and that the movement of bundled actin can be regulated photonically. These data suggest that actin bundling may significantly improve the applicability of the myosin motor for future nanotechnological applications.