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Label‐Free Colorimetric Detection of Small Molecules Utilizing DNA Oligonucleotides and Silver Nanoparticles
Author(s) -
Xu Xiaowen,
Wang Juan,
Yang Fan,
Jiao Kui,
Yang Xiurong
Publication year - 2009
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200901164
Subject(s) - oligonucleotide , dna , nanoparticle , silver nanoparticle , molecule , combinatorial chemistry , small molecule , nanotechnology , chemistry , adsorption , materials science , biochemistry , organic chemistry
Unmodified DNA and silver nanoparticles (AgNPs) are used to develop a colorimetric method for distinguishing ligands binding to homoadenine, based on DNA adsorption onto AgNPs (see picture). The targets of the label‐free assay could be small molecules rather than oligonucleotides.