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Sterilization Matters: Consequences of Different Sterilization Techniques on Gold Nanoparticles
Author(s) -
França Ángela,
Pelaz Beatriz,
Moros María,
SánchezEspinel Christian,
Hernández Andrea,
FernándezLópez Cristina,
Grazú Valeria,
de la Fuente Jesús M.,
PastorizaSantos Isabel,
LizMarzán Luis M.,
GonzálezFernández África
Publication year - 2010
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200901006
Subject(s) - sterilization (economics) , nanotechnology , nanoparticle , drug delivery , materials science , colloidal gold , biochemical engineering , business , engineering , finance , exchange rate , foreign exchange market
Nanoparticles (NPs) can offer many advantages over traditional drug design and delivery, as well as toward medical diagnostics. As with any medical device or pharmaceutical drug intended to be used for in vivo biomedical applications, NPs must be sterile. However, very little is known regarding the effect of sterilization methods on the intrinsic properties and stability of NPs. Herein a detailed analysis of physicochemical properties of two types of AuNPs upon sterilization by means of five different techniques is reported. In addition, cell viability and production of reactive oxygen species are studied. The results indicate that sterilization by ethylene oxide seems to be the most appropriate technique for both types of NPs. It is concluded that it is crucial to test several methods in order to establish the specific type of sterilization to be performed for each particular NP.