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Complementary Electrical and Spectroscopic Detection Assays with On‐Wire‐Lithography‐Based Nanostructures
Author(s) -
Zheng Gengfeng,
Chen Xiaodong,
Mirkin Chad A.
Publication year - 2009
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200901000
Subject(s) - nanostructure , lithography , materials science , nanotechnology , oligonucleotide , nanolithography , dna origami , dip pen nanolithography , nanoscopic scale , self assembly , optoelectronics , chemistry , dna , medicine , biochemistry , alternative medicine , pathology , fabrication
On‐wire lithography is used to synthesize a new nanostructure composed of a goldpolypyrrole segment and gold nanodisk pairs for parallel electrical and spectroscopic readout (see image). As proof‐of‐concept, the binding of telomerase to surface‐functionalized oligonucleotide receptors and subsequent elongation of the oligonucleotides are demonstrated by parallel electrical and spectroscopic measurements.