Premium
Detection of a Single Nucleotide Polymorphism Using Single‐Walled Carbon‐Nanotube Near‐Infrared Fluorescence
Author(s) -
Jeng Esther S.,
Nelson John D.,
Prather Kristala L. J.,
Strano Michael S.
Publication year - 2010
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200900944
Subject(s) - single nucleotide polymorphism , snp , carbon nanotube , fluorescence , dna , nucleotide , polymorphism (computer science) , dna sequencing , nanotechnology , gene , materials science , computational biology , biophysics , microbiology and biotechnology , genetics , biology , physics , genotype , optics
The detection of a single nucleotide polymorphism (SNP) using single‐walled carbon nanotube (SWNT) fluorescence is demonstrated for SWNTs coated in a probe DNA sequence (see image) via a fluorescence‐energy increase of only 0.8 meV upon addition of the complement containing a SNP. This mechanism is simple, label‐ and enzyme‐free, and the properties of the probe DNA that enable this detection are examined.