Premium
Polymer‐Protected Sub‐2‐nm‐Nanogap Fabrication for Biological Sensing in Near‐Physiological Conditions
Author(s) -
Zhang Huijuan,
Barsotti Robert J.,
Wong CheeLeong,
Xue Xuejia,
Liu Xiaogang,
Stellacci Francesco,
Thong John T. L.
Publication year - 2009
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200900938
Subject(s) - fabrication , nanotechnology , polymer , materials science , ionic bonding , oligonucleotide , nanoparticle , computer science , dna , chemistry , ion , medicine , biochemistry , alternative medicine , organic chemistry , pathology , composite material
Polymer‐protected sub‐2‐nm nanogaps that are fabricated via a novel electrical stressing approach exhibit substantial ionic‐current reduction in near‐physiological conditions. These devices enable direct DNA detection in aqueous solution by utilizing assembly of oligonucleotide‐modified gold nanoparticles to the nanogap (see image).