Premium
Sniffing the Unique “Odor Print” of Non‐Small‐Cell Lung Cancer with Gold Nanoparticles
Author(s) -
Barash Orna,
Peled Nir,
Hirsch Fred R.,
Haick Hossam
Publication year - 2009
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200900937
Subject(s) - sniffing , odor , lung cancer , colloidal gold , gold standard (test) , cancer , nanotechnology , biomedical engineering , materials science , computer science , nanoparticle , medicine , pathology , biology , neuroscience , anatomy
A highly sensitive and fast‐response array of sensors based on gold nanoparticles, in combination with pattern recognition methods, can distinguish between the odor prints of non‐small‐cell lung cancer and negative controls with 100% accuracy, with no need for preconcentration techniques. Additionally, preliminary results indicate that the same array of sensors might serve as a better tool for understanding the biochemical source of volatile organic compounds that might occur in cancer cells and appear in the exhaled breath, as compared to traditional spectrometry techniques. The reported results provide a launching pad to initiate a bedside tool that might be able to screen for early stages of lung cancer and allow higher cure rates. In addition, such a tool might be used for the immediate diagnosis of fresh (frozen) tissues of lung cancer in operating rooms, where a dichotomic diagnosis is crucial to guide surgeons.