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Intracellular Localization and Cytotoxicity of Spherical Mesoporous Silica Nano‐ and Microparticles
Author(s) -
He Qianjun,
Zhang Zhiwen,
Gao Yu,
Shi Jianlin,
Li Yaping
Publication year - 2009
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200900923
Subject(s) - cytotoxicity , mesoporous silica , pulmonary surfactant , nanoparticle , materials science , mesoporous material , particle (ecology) , particle size , extraction (chemistry) , chemical engineering , intracellular , nano , nanotechnology , calcination , nanoscopic scale , chemistry , chromatography , organic chemistry , composite material , in vitro , biochemistry , oceanography , geology , engineering , catalysis
This work evaluates the cytotoxicity of spherical mesoporous silica (MS) nano‐ and microparticles and investigates the effects of particle size, concentration, biodegradation products of MS, residual surfactant, and surfactant removal by extraction and calcination on the cytotoxicity. The results from the intracellular localization of spherical MS nano‐ and microparticles with different sizes reveal the mechanism for their cytotoxicity and that the smaller particles in nanoscale are more easily endocytosed and consequently located within lysosomes.