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Multiplex Imaging of Single Tumor Cells Using Quantum‐Dot‐Conjugated Aptamers
Author(s) -
Kang Won Jun,
Chae Ju Ri,
Cho Ye Lim,
Lee Jong Doo,
Kim Soonhag
Publication year - 2009
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200900848
Subject(s) - aptamer , quantum dot , conjugated system , multiplex , nanotechnology , cancer cell , tumor cells , chemistry , computational biology , biophysics , computer science , materials science , cancer , microbiology and biotechnology , biology , cancer research , bioinformatics , genetics , polymer , organic chemistry
Aptamers conjugated with quantum dots (QDs) bind to target molecules on the cellular membrane of cancer cells. QDs with a carboxyl terminal are conjugated with three types of tumor‐targeting aptamer (see picture). Various types of cancer cell are simultaneously targeted with QD‐TTA1 (605nm, light green), QD‐AS1411 (655nm, red), and QD‐MUC‐1 (705nm, violet).