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Synthetically Programmable DNA Binding Domains in Aggregates of DNA‐Functionalized Gold Nanoparticles
Author(s) -
Hurst Sarah J.,
Hill Haley D.,
Macfarlane Robert J.,
Wu Jinsong,
Dravid Vinayak P.,
Mirkin Chad A.
Publication year - 2009
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200900568
Subject(s) - dna , nanoparticle , colloidal gold , materials science , nanotechnology , biophysics , chemistry , biochemistry , biology
Nanoparticles that assemble into core/shell aggregate structures comprising thermally addressable, phase‐separated DNA binding domains are designed. Since the strength of the DNA binding in these domains differs, these aggregate systems exhibit two distinct melting transitions upon dehybridization (see image) resulting from the stepwise disassociation of the entire structure. These materials are ideal for probing the structure–function relationship of DNA‐linked nanoparticle aggregates.