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Control of the in vivo Biodistribution of Hybrid Nanoparticles with Different Poly(ethylene glycol) Coatings
Author(s) -
Faure AnneCharlotte,
Dufort Sandrine,
Josserand Véronique,
Perriat Pascal,
Coll JeanLuc,
Roux Stéphane,
Tillement Olivier
Publication year - 2009
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200900563
Subject(s) - biodistribution , ethylene glycol , nanoparticle , in vivo , materials science , peg ratio , gadolinium , fluorescence , preclinical imaging , fluorescence lifetime imaging microscopy , nanotechnology , biophysics , chemistry , organic chemistry , physics , microbiology and biotechnology , finance , quantum mechanics , metallurgy , economics , biology
Fluorescent nanoparticles containing a gadolinium oxide core are very attractive because they are able to combine both imaging (fluorescence imaging, magnetic resonance imaging) and therapy (X‐ray therapy and neutron‐capture therapy) techniques. The exploitation of these multifunctional particles for in vivo applications requires accurate control of their biodistribution. The postfunctionalization of these particles by four different poly(ethylene glycol) derivatives, which differ by chain length and end group, exerts a great influence on the ζ potential of the nanoparticles and on their biodistribution after intravenous injection to HEK‐ β 3‐tumor‐bearing mice. This study reveals that the behavior of PEGylated nanoparticles, which was monitored by in vivo fluorescence imaging, depends on both the chain length and the end group of the PEG chain.