Drug/Dye‐Loaded, Multifunctional Iron Oxide Nanoparticles for Combined Targeted Cancer Therapy and Dual Optical/Magnetic Resonance Imaging | Zendy

Santra Santimukul | Zendy; Kaittanis Charalambos | Zendy; Grimm Jan | Zendy; Perez J. Manuel | Zendy

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Drug/Dye‐Loaded, Multifunctional Iron Oxide Nanoparticles for Combined Targeted Cancer Therapy and Dual Optical/Magnetic Resonance Imaging

Author(s) -

Santra Santimukul,

Kaittanis Charalambos,

Grimm Jan,

Perez J. Manuel

Publication year - 2009

Publication title -

small

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 3.785

H-Index - 236

eISSN - 1613-6829

pISSN - 1613-6810

DOI - 10.1002/smll.200900389

Subject(s) - materials science , magnetic resonance imaging , nanoparticle , nanotechnology , photothermal therapy , magnetic nanoparticles , iron oxide nanoparticles , targeted drug delivery , biocompatible material , optical imaging , cancer therapy , drug delivery , biomedical engineering , cancer , medicine , physics , optics , radiology

Abstract A biocompatible, multimodal, and theranostic functional iron oxide nanoparticle is synthesized using a novel water‐based method and exerts excellent properties for targeted cancer therapy, and optical and magnetic resonance imaging. For the first time, a facile, modified solvent diffusion method is used for the co‐encapsulation of both an anticancer drug and near‐infrared dyes. The resulting folate‐derivatized theranostics nanoparticles could allow for targeted optical/magnetic resonance imaging and targeted killing of folate‐expressing cancer cells.

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