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Greatly Improved Blood Compatibility by Microscopic Multiscale Design of Surface Architectures
Author(s) -
Fan Honglei,
Chen Peipei,
Qi Ruomei,
Zhai Jin,
Wang Jingxia,
Chen Long,
Chen Li,
Sun Quanmei,
Song Yanlin,
Han Dong,
Jiang Lei
Publication year - 2009
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200900345
Subject(s) - polydimethylsiloxane , nanotechnology , compatibility (geochemistry) , computer science , lithography , materials science , platelet adhesion , architecture , soft lithography , adhesion , engineering drawing , mechanical engineering , engineering , composite material , optoelectronics , visual arts , fabrication , art , medicine , alternative medicine , pathology
A multiscale architecture with interlaced submicrometer ridges and nanoprotrusions is built on a polydimethylsiloxane (PDMS) surface by a combination of self‐assembly, soft lithography, and physical treatment (see picture). The multiscale structure reduces activated‐platelet adhesion under flow conditions, which is significant for the development of blood‐contacting materials.