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Design of Synthetic Polymer Nanoparticles that Capture and Neutralize a Toxic Peptide
Author(s) -
Hoshino Yu,
Urakami Takeo,
Kodama Takashi,
Koide Hiroyuki,
Oku Naoto,
Okahata Yoshio,
Shea Kenneth J.
Publication year - 2009
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200900186
Subject(s) - copolymer , polymer , nanoparticle , peptide , monomer , synthetic polymer , combinatorial chemistry , toxin , materials science , nanotechnology , chemistry , organic chemistry , biochemistry
Designed polymer nanoparticles (NPs) capable of binding and neutralizing a biomacromolecular toxin are prepared. A library of copolymer NPs is synthesized from combinations of functional monomers. The binding capacity and affinity of the NPs are individually analyzed. NPs with optimized composition are capable of neutralizing the toxin even in a complex biological milieu. It is anticipated that this strategy will be a starting point for the design of synthetic alternatives to antibodies.