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Pyrrole/Imidazole–Polyamide Anchors for DNA Tertiary Interactions
Author(s) -
Schmidt Thorsten L.,
Heckel Alexander
Publication year - 2009
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200900147
Subject(s) - polyamide , dna , oligonucleotide , crystallography , binding site , supramolecular chemistry , imidazole , sequence (biology) , covalent bond , chemistry , polymer science , nanotechnology , materials science , stereochemistry , biochemistry , polymer chemistry , organic chemistry , crystal structure
Tertiary interactions are introduced for DNA nanotechnology by covalently coupling a sequence‐specific DNA‐binding polyamide (“anchor”) to an oligonucleotide. By ligating this DNA–polyamide hybrid into a double‐stranded DNA circle that carries the binding site for the polyamide, the circles self‐assemble to form stable homodimeric complexes that are imaged by atomic force microscopy (see image).