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A Biochip Model of Lymphocyte Locomotion on Confined Chemokine Tracks
Author(s) -
Buxboim Am,
Geron Erez,
Alon Ronen,
BarZiv Roy
Publication year - 2009
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200900042
Subject(s) - biochip , chemokine , ccr10 , motility , chemokine receptor , stromal cell , materials science , microbiology and biotechnology , immunology , nanotechnology , biology , cancer research , inflammation
To simulate chemokine tracks presented by narrow stromal networks inside lymph nodes, novel biochips micropatterned with long chemokine stripes are fabricated. Chemokine‐coated regions induce T‐cell polarization and motility whereas T‐cells settling on chemokine‐free biochips remain round and static. Chemokine‐stimulated T‐cell motility is thus directed along patterned stripes (see time‐lapse images).