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DNA Aptamer‐Passivated Nanocrystal Synthesis: A Facile Approach for Nanoparticle‐Based Cancer Cell Growth Inhibition
Author(s) -
Choi Jong Hyun,
Chen Kok Hao,
Han JaeHee,
Chaffee Amanda M.,
Strano Michael S.
Publication year - 2009
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200801821
Subject(s) - aptamer , nanocrystal , nanotechnology , dna , nanoparticle , cancer cell , materials science , g quadruplex , cancer , chemistry , computational biology , microbiology and biotechnology , biology , biochemistry , genetics
A class of DNA aptamers , recognizing and therapeutically targeting cancer cells, remains functional while forming stable colloidal PbS and Fe 3 O 4 nanocrystals. The aptamer‐passivated nanocrystals (see image) are non‐cytotoxic to normal cells, whereas MCF‐7 human breast cancer cells incorporated with these particles have significantly reduced proliferation. The nanoparticle‐aptamer systems provide a platform for novel nanoparticle therapeutics.