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Synthesis of Cell‐Laden Alginate Hollow Fibers Using Microfluidic Chips and Microvascularized Tissue‐Engineering Applications
Author(s) -
Lee Kwang Ho,
Shin Su Jung,
Park Yongdoo,
Lee SangHoon
Publication year - 2009
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200801667
Subject(s) - microfluidics , tissue engineering , self healing hydrogels , nanotechnology , embedding , fabrication , process (computing) , computer science , materials science , biomedical engineering , engineering , polymer chemistry , artificial intelligence , pathology , medicine , alternative medicine , operating system
Alginate‐only , cell‐laden, and protein‐immobilized hollow fibers are produced (see image). Cells remain alive within the hollow fibers due to the nontoxic fabrication process. Vascular tissue can be emulated by embedding endothelial cells into the alginate hollow fibers and then embedding these cell‐laden fibers into smooth‐muscle‐cell‐laden AGF hydrogels.