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Functionalized Nanoparticles with Long‐Term Stability in Biological Media
Author(s) -
Fang Chen,
Bhattarai Narayan,
Sun Conroy,
Zhang Miqin
Publication year - 2009
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200801647
Subject(s) - ethylene glycol , nanoparticle , peg ratio , dispersity , biomolecule , amine gas treating , materials science , oleic acid , surface modification , nanotechnology , polymer chemistry , chemical engineering , chemistry , combinatorial chemistry , organic chemistry , biochemistry , finance , engineering , economics
A surface‐engineering approach to produce monodisperse nanoparticles functionalized for conjugations of various biomolecules is described. The oleic acid‐capped nanoparticles are modified with triethoxysilylpropylsuccinic anhydride followed by reaction with aminated poly(ethylene glycol) (PEG) to render the nanoparticles hydrophilic and display amine groups at the free termini of PEG chains (see image).