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TiO 2 Nanotube Surfaces: 15 nm—An Optimal Length Scale of Surface Topography for Cell Adhesion and Differentiation
Author(s) -
Park Jung,
Bauer Sebastian,
Schlegel Karl Andreas,
Neukam Friedrich W.,
von der Mark Klaus,
Schmuki Patrik
Publication year - 2009
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200801476
Subject(s) - adhesion , materials science , nanotube , mesenchymal stem cell , cell adhesion , nanotechnology , surface (topology) , titanium , composite material , microbiology and biotechnology , geometry , carbon nanotube , biology , mathematics , metallurgy
Using aligned TiO 2 nanotubes with different diameters in the range between 15 and 100 nm synthesized on titanium by an electrochemical approach, it is shown that 15 nm is a universal surface geometric constant that promotes cell adhesion, proliferation, migration, and differentiation of different cell types (such as mesenchymal stem cells and hematopoietic stem cells; see image).