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Notch Ligand Presenting Acellular 3D Microenvironments for ex vivo Human Hematopoietic Stem‐Cell Culture made by Layer‐By‐Layer Assembly
Author(s) -
Lee Jungwoo,
Kotov Nicholas A.
Publication year - 2009
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200801242
Subject(s) - ex vivo , stromal cell , stem cell , microbiology and biotechnology , haematopoiesis , notch signaling pathway , layer (electronics) , function (biology) , biology , in vivo , nanotechnology , materials science , cancer research , genetics , signal transduction
Notch ligands presenting artificial 3D thymic microenvironments are created on ICC scaffolds utilizing a layer‐by‐layer molecular assembly technique (see image). A multicomponent LBL film substitutes the function of thymic stromal cells and successfully supports ex vivo T‐cell differentiation of human hematopoietic stem cells.