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Mesoporous Silica Nanoparticles for Reducing Hemolytic Activity Towards Mammalian Red Blood Cells
Author(s) -
Slowing Igor I.,
Wu ChiaWen,
ViveroEscoto Juan L.,
Lin Victor S.Y.
Publication year - 2009
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200800926
Subject(s) - mesoporous silica , biocompatibility , amorphous silica , nanoparticle , nanotechnology , in vivo , amorphous solid , mesoporous material , materials science , chemistry , chemical engineering , biochemistry , biology , organic chemistry , microbiology and biotechnology , engineering , catalysis
The hemolytic properties of amorphous silica and MCM‐41‐type mesoporous silica nanoparticles (MSNs) with rabbit red blood cells (RBCs) are compared. The amorphous silica exhibits a high hemolytic activity toward the RBCs. In contrast, a high biocompatibility between the MSNs and the RBCs is observed. The low hemolytic activity of the MSNs offers promising potential for various in vivo biotechnological applications.