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Biodistribution of 1.4‐ and 18‐nm Gold Particles in Rats
Author(s) -
SemmlerBehnke Manuela,
Kreyling Wolfgang G.,
Lipka Jens,
Fertsch Stefanie,
Wenk Alexander,
Takenaka Shinji,
Schmid Günter,
Brandau Wolfgang
Publication year - 2008
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200800922
Subject(s) - biodistribution , colloidal gold , nanoparticle , biophysics , nanotechnology , materials science , chemistry , in vitro , biology , biochemistry
1.4‐nm gold nanoparticles (NPs) are observed to cross the air/blood barrier of the lungs much more efficiently than 18‐nm gold NPs (see figure). The NP accumulation pattern in the secondary‐target organs differs strongly from those seen after direct intravenous injection. From this, it is hypothesized that NPs interact dynamically with proteins and cells, which determines their accumulation in the various organs.