Premium
Repairing the Damaged Spinal Cord and Brain with Nanomedicine
Author(s) -
Cho Youngnam,
Shi Riyi,
Borgens Richard,
Ivanisevic Albena
Publication year - 2008
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200800838
Subject(s) - spinal cord , spinal cord injury , peg ratio , polyethylene glycol , ex vivo , nanomedicine , in vivo , medicine , anatomy , materials science , chemistry , biology , nanotechnology , nanoparticle , biochemistry , microbiology and biotechnology , finance , psychiatry , economics
Polyethylene glycol (PEG)‐coated silica colloids circulating in the bloodstream target only injured tissues, particularly a spinal‐cord injury (see picture). The PEG coating both seals and induces repair of damaged cells, leading to a recovery of physiological function. These PEG‐coated colloids have been characterized, tested in ex vivo spinal cord and in living adult Guinea pig spinal‐cord injury.