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Lipid–Gold‐Nanoparticle Hybrid‐Based Gene Delivery
Author(s) -
Rhim WonKyu,
Kim JinSoo,
Nam JwaMin
Publication year - 2008
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200800628
Subject(s) - gene delivery , colloidal gold , dna , nanoparticle , nanotechnology , materials science , plasmid , gene , genetic enhancement , chemistry , biochemistry
Lipid‐plasmid DNA(pDNA)‐gold nanoparticle(AuNP) hybrids are synthesized and used for gene delivery (see image). The loading of DNA strands onto AuNPs allows for their support and stabilization by the NPs; many DNA strands are delivered per delivery event. These results show that lipids and AuNP in one hybrid can work synergistically for improved gene delivery.