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Biocompatible Polymer‐Nanoparticle‐Based Bimodal Imaging Contrast Agents for the Labeling and Tracking of Dendritic Cells
Author(s) -
Lim Yong Taik,
Noh YoungWoock,
Han Jung Hyun,
Cai QuanYu,
Yoon KwonHa,
Chung Bong Hyun
Publication year - 2008
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200800582
Subject(s) - indocyanine green , nanoparticle , contrast (vision) , fluorescence lifetime imaging microscopy , magnetic resonance imaging , biocompatible material , fluorescence , materials science , nanotechnology , biomedical engineering , computer science , medicine , optics , pathology , radiology , computer vision , physics
What a contrast! Agents for both magnetic resonance imaging (MRI) and near‐infrared (NIR) fluorescence imaging are synthesized by encapsulating iron oxide nanoparticles and indocyanine green in a poly(lactide‐ co ‐glycolide) matrix. The migration of dendritic cells (DCs) via lymphatic drainage is monitored by real‐time NIR fluorescence imaging, and the tracking of DCs into lymph nodes is achieved through noninvasive MRI (see picture).