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Soybeans as a Phytochemical Reservoir for the Production and Stabilization of Biocompatible Gold Nanoparticles
Author(s) -
Shukla Ravi,
Nune Satish K.,
Chanda Nripen,
Katti Kavita,
Mekapothula Swapna,
Kulkarni Rajesh R.,
Welshons Wade V.,
Kannan Raghuraman,
Katti Kattesh V.
Publication year - 2008
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200800525
Subject(s) - colloidal gold , nanomedicine , nanoparticle , nanotechnology , phytochemical , chemistry , materials science , biochemistry
The present study demonstrates an unprecedented green process for the production of gold nanoparticles by simple treatment of gold salts with soybean extracts. Reduction capabilities of antioxidant phytochemicals present in soybean and their ability to reduce gold salts chemically to nanoparticles with subsequent coating of proteins and a host of other phytochemicals present in soybean on the freshly generated gold nanoparticles are discussed. The new genre of green nanoparticles exhibit remarkable in vitro stability in various buffers including saline, histidine, HSA, and cysteine solutions. MTT assays reveal that the green gold nanoparticles are nontoxic and thus provide excellent opportunities for their applications in nanomedicine for molecular imaging and therapy. The overall strategy described herein for the generation of gold nanoparticles meets all 12 principles of green chemistry, as no “man‐made” chemicals, other than the gold salts, are used in the green nanotechnological process.