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Cell‐Compatible, Multicomponent Protein Arrays with Subcellular Feature Resolution
Author(s) -
Mei Ying,
Cannizzaro Christopher,
Park Hyoungshin,
Xu Qiaobing,
Bogatyrev Said R.,
Yi Kevin,
Goldman Nathan,
Langer Robert,
Anderson Daniel G.
Publication year - 2008
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200800363
Subject(s) - microscale chemistry , extracellular matrix , feature (linguistics) , resolution (logic) , extracellular , component (thermodynamics) , materials science , biological system , molecular biophysics , microbiology and biotechnology , nanotechnology , biophysics , chemistry , computer science , biology , artificial intelligence , physics , biochemistry , mathematics , linguistics , mathematics education , thermodynamics , philosophy
Microscale direct writing (MDW) technology is developed for the generation of complex extracellular Matrix (ECM) protein arrays at subcellular feature size with multiple components. Cell‐compatible, two‐component ECM protein arrays with a feature size of 6–9 micrometers (see image) are systematically generated with varying spacing and composition, and their effects on cellular attachment and spreading of a model cell line, mouse myofibroblasts, are evaluated.