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Adenovirus Knob Trimers as Tailorable Scaffolds for Nanoscale Assembly
Author(s) -
Maye Mathew M.,
Freimuth Paul,
Gang Oleg
Publication year - 2008
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200800177
Subject(s) - self assembly , nanotechnology , nanoscopic scale , materials science , nanoparticle , nanostructure , colloidal gold , hinge , chemistry , physics , classical mechanics
The biomimetic assembly of nanoparticles into controllable nanostructures hinges on the ability to regulate system reactivity. The introduction of structural elements with predesigned symmetries and quantized number of binding sites may aid in this effort. Symmetric adenovirus knob proteins are used as scaffolds for nano‐assembly (see image). By way of genetic mutation, solvent‐accessible Cys residues are incorporated onto a knob's trimeric surface, and the resulting symmetric tridentate crosslinker is shown to possess tunable assembly characteristics with gold nanoparticles.