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Triple Constructs Consisting of Nanoparticles and Microspheres for Bone‐Marrow‐Derived Stromal‐Cell‐Delivery Microscaffolds
Author(s) -
Park Ji Sun,
Park Kyeongsoon,
Woo Dae Gyun,
Yang Han Na,
Chung HyungMin,
Park KeunHong
Publication year - 2008
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200701315
Subject(s) - stromal cell , plga , glycolic acid , nanoparticle , microsphere , bone marrow , nanotechnology , materials science , layer (electronics) , biomedical engineering , computer science , chemistry , chemical engineering , lactic acid , medicine , cancer research , pathology , engineering , biology , bacteria , genetics
The effective stabilization of 2‐ and 3D assemblies of heparin/poly(l‐lysine) nanoparticles is achieved through embedment in DHEA‐ and DEXA‐loaded poly(l‐lactic‐co‐glycolic acid) (PLGA) microspheres (see image). These structures, which have great potential for use in cell delivery and for tissue regeneration, are manufactured using layer‐by‐layer electrostatic self‐assembly, and are shown to have a positive effect on bone‐marrow stromal cell aggregation and differentiation.