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A Multimodal Targeting Nanoparticle for Selectively Labeling T Cells
Author(s) -
Gunn Jonathan,
Wallen Herschel,
Veiseh Omid,
Sun Conroy,
Fang Chen,
Cao Jianhong,
Yee Cassian,
Zhang Miqin
Publication year - 2008
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200701103
Subject(s) - ctl* , nanoparticle , major histocompatibility complex , fluorescence microscope , peptide , biophysics , fluorescence , cytotoxic t cell , nanotechnology , materials science , chemistry , biochemistry , biology , in vitro , gene , physics , quantum mechanics
A nanoparticle system capable of selectively labeling and monitoring antigen‐specific cytotoxic T lymphocytes (CTLs) by magnetic resonance imaging and fluorescence reporting is demonstrated. These targeting nanoparticles were functionalized with tumor‐specific peptide‐major histocompatibility complex (MHC) (see figure). TEM and fluorescence microscopy reveal nanoparticle binding to the CTL membrane.