Premium
Carbon Nanotubes Conjugated to Tumor Lysate Protein Enhance the Efficacy of an Antitumor Immunotherapy
Author(s) -
Meng Jie,
Meng Jie,
Duan Jinhong,
Kong Hua,
Li Li,
Wang Chen,
Xie Sishen,
Chen Shuchang,
Gu Ning,
Xu Haiyan,
Yang XianDa
Publication year - 2008
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200701059
Subject(s) - immunotherapy , immune system , conjugated system , lysis , cancer research , cancer immunotherapy , carbon nanotube , tumor cells , materials science , medicine , nanotechnology , immunology , polymer , composite material
Abstract The biomedical applications of carbon nanotubes (CNTs) have attracted deep interest in recent years. Antitumor immunotherapy has the potential to improve the prognosis of cancer treatment but the efficacy of current immunotherapy generally needs further improvement. Multi‐walled CNTs conjugated to tumor lysate protein are investigated as to whether they would enhance the efficacy of an immunotherapy employing a tumor‐cell vaccine in a mouse model bearing the H22 liver cancer. The tumor cure rate is found to be markedly improved by CNTs conjugated to tumor lysate protein. The cellular antitumor immune reaction is also enhanced. Moreover, the observed antitumor immune response is relatively specific against the tumor intended for treatment. These findings suggest that CNTs may have a prospective role in the development of new antitumor immunotherapies.