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Fabrication of Colloidal Crystal Beads by a Drop‐Breaking Technique and Their Application as Bioassays
Author(s) -
Sun Cheng,
Zhao XiangWei,
Zhao YuanJin,
Zhu Rong,
Gu ZhongZe
Publication year - 2008
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200701026
Subject(s) - analyte , multiplex , bead , dispersity , immunoassay , fluorescence , materials science , drop (telecommunication) , fabrication , chromatography , bioassay , colloid , nanotechnology , colloidal crystal , biosensor , chemistry , antibody , biology , optics , polymer chemistry , organic chemistry , immunology , composite material , alternative medicine , pathology , computer science , telecommunications , medicine , bioinformatics , physics , genetics
Colored beads: Monodisperse colloidal crystal beads with structural colors are used for multiplex immunoassay as encoded biomolecular supports. Mouse, rabbit, and human immunoglobulin G (IgG) are immobilized on blue, green, and red beads, respectively, and incubated with the analyte. The fluorescence peaks for the blue and green beads imply that the analyte contains tagged antimouse IgG and antirabbit IgG only (see picture).