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Synthesis of Biocompatible Dextran‐Coated Nanoceria with pH‐Dependent Antioxidant Properties
Author(s) -
Perez J. Manuel,
Asati Atul,
Nath Sudip,
Kaittanis Charalambos
Publication year - 2008
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200700824
Subject(s) - biocompatible material , dextran , antioxidant , cytoprotection , cerium oxide , chemistry , nanoparticle , nanotechnology , chemical engineering , materials science , oxide , biochemistry , biomedical engineering , organic chemistry , oxidative stress , engineering
Biocompatible dextran‐coated nanoceria (cerium oxide nanoparticles) are found to exhibit excellent, pH‐dependent antioxidant properties (see image). They provide cytoprotection from free radicals to normal cells but not to cancer cells, and thus have potential applications in antioxidant and anti‐inflammatory coatings for prosthetic devices and tissue engineering and in improved cancer therapeutics.