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Multifunctional Nanoparticles for Photothermally Controlled Drug Delivery and Magnetic Resonance Imaging Enhancement
Author(s) -
Park Huiyul,
Yang Jaemoon,
Seo Sungbaek,
Kim Kyujung,
Suh Jinsuk,
Kim Donghyun,
Haam Seungjoo,
Yoo KyungHwa
Publication year - 2008
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200700807
Subject(s) - plga , nanoparticle , materials science , drug delivery , nanotechnology , rhodamine , rhodamine b , magnetic resonance imaging , irradiation , chemical engineering , chemistry , optics , organic chemistry , fluorescence , photocatalysis , medicine , physics , engineering , nuclear physics , radiology , catalysis
Core–multishell nanoparticles: Near‐IR‐resonant rhodamine‐encapsulated poly(lactic‐ co ‐glycolic acid) (PLGA)–Mn/Au half‐shell nanoparticles (NPs; see figure) are developed by depositing metal multilayers on PLGA NPs. These NPs can be used for photothermally controlled drug delivery and magnetic resonance imaging. Upon NIR irradiation, the release rate of rhodamine from the PLGA NPs is about twice as great as that without NIR irradiation, indicating photothermally controlled drug delivery possibilities.