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Covalently PEGylated Carbon Nanotubes with Stealth Character In Vivo
Author(s) -
Yang ShengTao,
Fernando K. A. Shiral,
Liu JiaHui,
Wang Jing,
Sun HongFang,
Liu Yuanfang,
Chen Min,
Huang Yipu,
Wang Xin,
Wang Haifang,
Sun YaPing
Publication year - 2008
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200700714
Subject(s) - carbon nanotube , in vivo , covalent bond , materials science , nanotechnology , drug delivery , character (mathematics) , nanotube , chemistry , organic chemistry , biology , geometry , microbiology and biotechnology , mathematics
Stealth nanotubes : The stealth character of covalently PEGylated single‐walled nanotubes (SWNTs, indicated by arrows in image) in vivo is studied. The nanotubes exhibit much longer blood‐circulation half‐life in vivo than the previous record for nanotubes and also a low hepatic uptake, vital to uses in drug‐delivery systems. The benefits are reflected in the observed high tumor uptake of PEGylated SWNTs.