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In Vivo Monitoring of Intravenously Injected Gold Nanorods Using Near‐Infrared Light
Author(s) -
Niidome Takuro,
Akiyama Yasuyuki,
Shimoda Kohei,
Kawano Takahito,
Mori Takeshi,
Katayama Yoshiki,
Niidome Yasuro
Publication year - 2008
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200700438
Subject(s) - nanorod , absorbance , materials science , plasmon , polyethylene glycol , analytical chemistry (journal) , nanotechnology , chemical engineering , chemistry , optoelectronics , chromatography , engineering
Gold nanorods showing surface plasmon (SP) bands in the near‐IR region are used as bioimaging probes that respond to near‐IR light in mice. The SP bands of intravenously injected polyethylene glycol‐modified gold nanorods are directly monitored from the mouse abdomen by using a spectrophotometer equipped with an integrating sphere. The absorbance at 900 nm from the gold nanorods immediately increases after injection and reaches a plateau. The injection of phosphatidylcholine‐modified gold nanorods also increases the absorbance at 900 nm, but the absorbance decreases single exponentially with a 1.3‐min half‐life. In vivo spectral changes of gold nanorods depend on the surface characteristics, and can be observed in real time using simple spectroscopic measurements.