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Stretched Cavity‐Assisted Molding of Micrometer and Submicrometer Photopolymerized Hydrogel Particles
Author(s) -
Laulia Philips,
ChanPark Mary B,
Yan Yehai,
Wang Shen Qi,
Li Chang Ming,
Lam Yee Cheong
Publication year - 2008
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200700323
Subject(s) - dispersity , materials science , nanotechnology , micrometer , drug delivery , bovine serum albumin , nanoparticle , particle (ecology) , molding (decorative) , particle size , biomedical engineering , chemical engineering , chemistry , composite material , chromatography , polymer chemistry , physics , optics , medicine , oceanography , engineering , geology
Stretched cavity‐assisted molding of particles is a novel method that can produce monodisperse submicrometer hydrogel particles (see image) loaded with a model protein drug, fluorescein‐isothiocyanate‐conjugated bovine serum albumin. The method avoids agitation, solvents, and high‐energy input by forming the particles inside preformed cavities. This method has the potential to be generalized to prepare multilayered or targeted particles containing fragile drugs for the pharmaceutical industry.