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Iridium‐Complex‐Functionalized Fe 3 O 4 /SiO 2 Core/Shell Nanoparticles: A Facile Three‐in‐One System in Magnetic Resonance Imaging, Luminescence Imaging, and Photodynamic Therapy
Author(s) -
Lai ChihWei,
Wang YuHsiu,
Lai ChengHsuan,
Yang MengJu,
Chen ChunYen,
Chou PiTai,
Chan ChiShun,
Chi Yun,
Chen YuChun,
Hsiao JongKai
Publication year - 2008
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200700283
Subject(s) - iridium , phosphorescence , materials science , luminescence , singlet oxygen , nanoparticle , magnetic resonance imaging , nanotechnology , nanocomposite , photochemistry , photodynamic therapy , core (optical fiber) , magnetic core , shell (structure) , optoelectronics , fluorescence , chemistry , oxygen , optics , electromagnetic coil , catalysis , composite material , organic chemistry , medicine , physics , electrical engineering , engineering , radiology
Highly uniform Fe 3 O 4 /SiO 2 core/shell nanoparticles functionalized by phosphorescent iridium complexes (Ir) have been strategically designed and synthesized. The Fe 3 O 4 /SiO 2 (Ir) nanocomposite demonstrates its versatility in various applications: the magnetic core provides the capability for magnetic resonance imaging and the great enhancement of the spin–orbit coupling in the iridium complex makes it well suited for phosphorescent labeling and simultaneous singlet oxygen generation to induce apoptosis.