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Intercalating Gold Nanoparticles as Universal Labels for DNA Detection
Author(s) -
Mehrabi Maryam,
Wilson Robert
Publication year - 2007
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200700230
Subject(s) - intercalation (chemistry) , nanoparticle , colloidal gold , dna , nanotechnology , double stranded , planar , computer science , chemistry , materials science , combinatorial chemistry , biochemistry , computer graphics (images) , organic chemistry
Stuck in the middle : Intercalators are small planar molecules that insert specifically between adjacent bases in double‐stranded DNA (see picture). Gold nanoparticles coated with intercalators are inexpensive universal labels that allow PCR products that have been hybridized to arrays of single‐stranded capture probes to be seen with the unaided eye.