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Sequence‐Specific DNA Detection Using High‐Affinity LNA‐Functionalized Gold Nanoparticles
Author(s) -
McKenzie Fiona,
Faulds Karen,
Graham Duncan
Publication year - 2007
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200700225
Subject(s) - colloidal gold , dna , nucleic acid , surface modification , locked nucleic acid , combinatorial chemistry , nanoparticle , nanotechnology , chemistry , materials science , biochemistry , oligonucleotide
Lock and load : The functionalization of gold nanoparticles with locked nucleic acid (LNA; see image) is reported. These nanoconjugate probes offer immense stability and selectivity towards complementary DNA, allowing the detection of specific DNA sequences.