Premium
Using Magnetic Force to Enhance Immune Response to DNA Vaccine
Author(s) -
Zhou XianFeng,
Liu Bin,
Yu XiangHui,
Zha Xiao,
Zhang XiZhen,
Wang XueYun,
Jin YingHua,
Wu YongGe,
Jiang ChunLai,
Chen Yue,
Chen Yan,
Shan YaMing,
Liu JunQiu,
Kong Wei,
Shen JiaCong
Publication year - 2007
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200700151
Subject(s) - immunogenicity , dna vaccination , dna , immune system , vector (molecular biology) , naked dna , transfection , immunization , virology , gene , recombinant dna , biology , immunology , genetics
The improvement of the gene distribution within skeletal muscle to enhance the immunogenicity of DNA vaccines is reported. Magnetic force acting on DNA vaccine associated with magnetic nanoparticles (see image), the major potential of which lies in extraordinarily rapid and efficient transfection at low vector doses, is utilized. After immunization, the magnetic DNA vector induces significantly enhanced serum antibody responses 2–3 orders of magnitude greater than naked DNA.