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Hybridization Kinetics and Thermodynamics of DNA Adsorbed to Individually Dispersed Single‐Walled Carbon Nanotubes
Author(s) -
Jeng Esther S.,
Barone Paul W.,
Nelson John D.,
Strano Michael S.
Publication year - 2007
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200700141
Subject(s) - carbon nanotube , kinetics , materials science , adsorption , thermodynamics , carbon fibers , chemical engineering , nanotechnology , chemistry , composite material , physics , composite number , quantum mechanics , engineering
Hybridization of DNA adsorbed to single‐walled carbon nanotubes in solution has much slower kinetics than free solution DNA, and can be detected through a blue shift in the near‐infrared nanotube fluorescence. Adsorption of the receptor DNA strand to the nanotube surface is consistent with models of polyelectrolyte adsorption on charged surfaces, introducing both entropic (46.8 cal mol −1 K −1 ) and activation energy (20.4 kcal mol −1 ) barriers to the hybridization, which are greater than free solution values (31.9 cal mol −1 K −1 and 12.9 kcal mol −1 ) at 25 °C. The increased hybridization barriers on the nanotube result in exceedingly slow kinetics for hybridization with t 1/2 =3.4 h, compared to the free solution value of t 1/2 =4 min. These results have significant implications for nanotube and nanowire biosensors.