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Nanopore Unstacking of Single‐Stranded DNA Helices
Author(s) -
Chen Peng,
Li Chang Ming
Publication year - 2007
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200700049
Subject(s) - nanopore , cooperativity , chromosomal translocation , dna , sequence (biology) , chemistry , biophysics , nanotechnology , biology , materials science , biochemistry , gene
Time to unwind : The force‐induced unstacking of individual single‐stranded homopolymeric DNA helices is demonstrated during their translocation through an α‐hemolysin protein nanopore by electrophoresis (see picture). The unstacking energy and sequence‐specific cooperativity are inferred from an analysis of the translocation kinetics.