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In Vitro and In Vivo Enzymatic Formation of Supramolecular Hydrogels Based on Self‐Assembled Nanofibers of a β‐Amino Acid Derivative
Author(s) -
Yang Zhimou,
Liang Gaolin,
Ma Manlung,
Gao Yuan,
Xu Bing
Publication year - 2007
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200700015
Subject(s) - self healing hydrogels , in vivo , peptide , supramolecular chemistry , nanofiber , dephosphorylation , in vitro , materials science , enzyme , chemistry , biophysics , nanotechnology , combinatorial chemistry , phosphatase , biochemistry , polymer chemistry , organic chemistry , molecule , biology , microbiology and biotechnology
A precursor of a β‐peptide derivative transforms into a hydrogelator and forms supramolecular hydrogels upon phosphatase‐catalyzed dephosphorylation. This new strategy works in vitro and in vivo (see image). The enzymatic hydrogelation in vivo indicates that the β‐peptide‐based hydrogel exhibits a longer lifetime than that of α‐peptide hydrogel in a subcutaneous environment. Such an excellent in vivo stability renders the β‐peptide‐based hydrogel as a potential candidate for biomedical applications.