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Accurate Immobilization of Antibody‐Functionalized Peptide Nanotubes on Protein‐Patterned Arrays by Optimizing their Ligand–Receptor Interactions
Author(s) -
Zhao Zheyuan,
Matsui Hiroshi
Publication year - 2007
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200700006
Subject(s) - materials science , molecule , nanotechnology , peptide , ligand (biochemistry) , inert , biophysics , chemical engineering , receptor , chemistry , organic chemistry , biochemistry , engineering , biology
Target practice: Antibody‐coated nanotubes can selectively attach to antigen‐containing trenches (see image) that are written by an AFM tip on a surface. The attachment depends on the concentration of the antigen in the trenches and can be tuned by using spacer molecules. It is shown that maximum filling is achieved (nearly 100 %) when the concentration of antigen is diluted to 7 % with inert spacer molecules.