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Mesoporous Silica Nanoparticles as a Delivery System for Hydrophobic Anticancer Drugs
Author(s) -
Lu Jie,
Liong Monty,
Zink Jeffrey I.,
Tamanoi Fuyuhiko
Publication year - 2007
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200700005
Subject(s) - mesoporous silica , camptothecin , drug delivery , nanoparticle , nanotechnology , anticancer drug , cancer therapy , cancer cell , cancer , materials science , drug , chemistry , combinatorial chemistry , mesoporous material , pharmacology , organic chemistry , medicine , catalysis
Special delivery : The hydrophobic anticancer drug camptothecin was incorporated into fluorescent mesoporous silica nanoparticles (see image) and delivered to various cancer cells to induce cell death. These results suggest a method to overcome the insolubility problem of many anticancer drugs, which is considered to be one of the major challenges in cancer therapy.