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Cover Picture: Selective Loading of Kinesin‐Powered Molecular Shuttles with Protein Cargo and its Application to Biosensing (Small 3/2006)
Author(s) -
Ramachandran Sujatha,
Ernst KarlHeinz,
Bachand George D.,
Vogel Viola,
Hess Henry
Publication year - 2006
Publication title -
small
Language(s) - English
Resource type - Reports
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200690008
Subject(s) - kinesin , biotinylation , motor protein , biosensor , microtubule , streptavidin , myoglobin , analyte , molecular motor , nanotechnology , biophysics , chemistry , microbiology and biotechnology , materials science , biochemistry , chromatography , biology , biotin
The cover picture illustrates a functionalized microtubule transported by surface‐adhered kinesin motor proteins. Through a streptavidin bridge, biotinylated antibodies are attached to the microtubule (outer diameter of 24 nm) and are able to capture antigens, such as the heart attack marker myoglobin. Successful capture is reported via the binding of fluorescently‐labeled antibodies, which complete the double‐antibody sandwich assay on the microtubule. The motor‐driven, active transport of this nanoscale bioassay will enable further separation and concentration, as well as sensitive detection. For more information please read the Communication "Selective Loading of Kinesin‐Powered Molecular Shuttles with Protein Cargo and its Application to Biosensing" by H. Hess and co‐workers on page 330 ff.