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In Situ Detection of Chromogranin A Released from Living Neurons with a Single‐Walled Carbon‐Nanotube Field‐Effect Transistor
Author(s) -
Wang ChenWei,
Pan ChienYuan,
Wu HsingChen,
Shih PoYuan,
Tsai ChiaChang,
Liao KuoTang,
Lu LiLong,
Hsieh WenHsing,
Chen ChiiDong,
Chen YitTsong
Publication year - 2007
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200600723
Subject(s) - carbon nanotube , transistor , chromogranin a , materials science , field effect transistor , in situ , carbon nanotube field effect transistor , nanotechnology , nanotube , sensitivity (control systems) , optoelectronics , chemistry , electronic engineering , biology , electrical engineering , voltage , organic chemistry , immunohistochemistry , immunology , engineering
Transistors tune in : The chromogranin A (CgA) released from the synaptic terminal of cortical neurons can be detected in situ by immobilization of an antibody against CgA on a single‐walled carbon‐nanotube field‐effect transistor (see picture), to give a device with high selectivity, sensitivity, and real‐time detection capability. This biosensory technique can be used to study the activity of individual living neurons.