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Creating Ultrathin Nanoscopic Collagen Matrices For Biological And Biotechnological Applications
Author(s) -
Cisneros David A.,
Friedrichs Jens,
Taubenberger Anna,
Franz Clemens M.,
Muller Daniel J.
Publication year - 2007
Publication title -
small
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 3.785
H-Index - 236
eISSN - 1613-6829
pISSN - 1613-6810
DOI - 10.1002/smll.200600598
Subject(s) - nanoscopic scale , nanotechnology , materials science , adhesion , biophysics , collagen fibril , biology , composite material
Abstract The biofunctionalization of materials creates interfaces on which proteins, cells, or tissues can fulfill native or desired tasks. Here we report how to control the assembly of type I collagen into well‐defined nanoscopic matrices of different patterns. Collagen fibrils in these ultrathin (≈3 nm) matrices maintained their native structure as observed in vivo. This opens up the possibility to create programmable biofunctionalized matrices using collagen‐binding proteins or proteins fused with collagen‐binding domains. Applied to eukaryotic cells, these nanostructured matrices can direct cellular processes such as adhesion, orientation and migration.